TXNIP Links Redox Circuitry to Glucose Control
نویسندگان
چکیده
منابع مشابه
Identification of Redox and Glucose-Dependent Txnip Protein Interactions
Thioredoxin-interacting protein (Txnip) acts as a negative regulator of thioredoxin function and is a critical modulator of several diseases including, but not limited to, diabetes, ischemia-reperfusion cardiac injury, and carcinogenesis. Therefore, Txnip has become an attractive therapeutic target to alleviate disease pathologies. Although Txnip has been implicated with numerous cellular proce...
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BACKGROUND Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure. METHODS AND FINDINGS We combined human insulin/glucose clamp physiological studies with genome-wide expression profiling t...
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In many physiological contexts, intracellular reduction-oxidation (redox) conditions and the unfolded protein response (UPR) are important for the control of cell life and death decisions. UPR is triggered by the disruption of endoplasmic reticulum (ER) homeostasis, also known as ER stress. Depending on the duration and severity of the disruption, this leads to cell adaptation or demise. In thi...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2007
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2007.05.011